This is an outdated version published on 2023-02-27. Read the most recent version.

Antibiotic Use Study in ICU/HCU of Muhammadiyah University General Hospital Malang using DDD and Gyssens Methods

Authors

  • Hidajah Rachmawati Apothecary Study Program Faculty of Health Sciences Universitas Muhammadiyah Malang
  • Muktamiroh Muktamiroh Pharmacy Study Program Faculty of Health Sciences Universitas Muhammadiyah Malang
  • Didik Hasmono Faculty of Pharmacy Universitas Airlangga Surabaya
  • Atika Putri Kusumaningtyas Muhammadiyah University General Hospital Malang
  • Sendi Lia Yunita Pharmacy Study Program Faculty of Health Sciences Universitas Muhammadiyah Malang
  • Lilik Yusetyani Apothecary Study Program Faculty of Health Sciences Universitas Muhammadiyah Malang

DOI:

https://doi.org/10.21776/ub.jkb.2023.032.03.7

Keywords:

Antibiotic, Defined Daily Dose, gyssens

Abstract

Infection is a condition caused by the propagation of harmful microorganisms with or without clinical symptoms. Improper use of antibiotics can lead to antibiotic resistance. The Ministry of Health of the Republic of Indonesia recommended a quantitative evaluation of the use of antibiotics using the Defined Daily Dose (DDD) method and a qualitative evaluation using the Gyssens method. This study evaluated antibiotics usage using DDD and Gyssens methods in ICU/HCU of the Muhammadiyah University General Hospital Malang. Employing retrospective observational method, data were collected from patient medical records hospitalized during January-December 2020. Results of the DDD quantitative analysis showed that the most widely used antibiotic was Ceftriaxone with a 35.79 DDD/100 patient-days. The Gyssenss qualitative analysis showed that the category VI (incomplete patient's medical record data) was 3%, category IVa (antibiotic use is more effective) (2%), category IIIb (duration of antibiotic use is too short) (3%), category IIb (antibiotic use is not at the right interval) (3%).

Downloads

Download data is not yet available.

References

Jun CH, Park CH, Lee WS, et al. Antibiotic Prophylaxis Using Third Generation Cephalosporins Can Reduce the Risk of Early Rebleeding in the First Acute Gastroesophageal Variceal Hemorrhage: A Prospective Randomized Study. Journal of Korean Medical Science. 2006; 21(5): 883–890.

Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia No. 28 Tahun 2021 tentang Pedoman Penggunaan Antibiotik. Jakarta: Kemenkes RI; 2021; p. 1-97.

World Health Organization. Antimicrobial Resistance: Global Report on Surveillance. Geneva: WHO; p. 619-635.

Rhodes A, Evans LE, Alhazzani W, et al. Serviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Medicine. 2017; 43(3): 304–377.

Sakr Y, Jaschinski U, Wittebole X, et al. Sepsis in Intensive Care Unit Patients: Worldwide Data from the Intensive Care Over Nations Audit. Open Forum Infectious Disease. 2018; 5(12): 1–9.

Gay L, Melenotte C, Lakbar I, et al. Sexual Dimorphism and Gender in Infectious Diseases. Frontiers in Immunology. 2021; 12: 1–16.

Banerjee D and Opal SM. Age, Exercise, and the Outcome of Sepsis. Critical Care. 2017; 21(1): 1-3.

Watkins RR and Bonomo RA. Overview: Global and Local Impact of Antibiotic Resistance. Infectious Disease Clinics of North America. 2016; 30(2): 313–322.

Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia No. 2406 tentang Pedoman Umum Penggunaan Antibiotik. Jakarta: Kemenkes RI; 2011; p. 34-44.

Sitompul F, Radji M, and Bahtiar A. Evaluation of Antibiotic used with Gyssens Method on Stroke Inpatient at RSUD Koja using Retrospective Approach (KJS and BPJS Period). Jurnal Kefarmasian Indonesia. 2016; 6(1): 30–38.

Sundariningrum RW, Setyanto DB, and Natadidjaja RI. Evaluasi Kualitatif Antibiotik Metode Gyssens dengan Konsep Regulasi Antimikroba Sistem Prospektif RASPRO pada Pneumonia di Ruang Rawat Intensif Anak. Sari Pediatri. 2020; 22(2): 109–114.

Lawry LL, Lugo-Robles R, and McIver V. Improvements to a Framework for Gender and Emerging Infectious Diseases. Bulletin of the World Health Organization. 2021; 99(9): 682–684.

Tambajong RN, Lalenoh DC, and Kumaat L. Profil Penderita Sepsis Di ICU RSUP Prof. Dr. R. D. Kandou Manadoperiode Desember 2014 – November 2015. e-CliniC. 2016; 4(1): 452–457.

Mariana N, Indriyati, Widiantari AD, et al. Gambaran Kuantitatif Antibiotik Berdasarkan Metode Defined Daily Dose di RSPI Sulianti Saroso pada Januari-Juni 2019. Pharmaceutical Journal of Indonesia. 2021; 7(1): 37–41.

Lubis IK and Susilawati. Analisis Length of Stay (Los) Berdasarkan Faktor Prediktor pada Pasien DM Tipe II di RS PKU Muhammadiyah Yogyakarta. Jurnal Kesehatan Vokasional. 2017; 2(2): 161–166.

Sakr Y, Elia C, Mascia L, Barberis B, et al. The Influence of Gender on the Epidemiology of and Outcome from Severe Sepsis. Critical Care. 2013; 17(2): 1–9.

Prahasanti K. Gambaran Infeksi pada Usia Lanjut. Qanun Media. 2019; 3(1): 81–91.

Starr ME and Saito H. Sepsis in Old Age: Review of Human and Animal Studies. Aging Disease. 2014; 5(2): 126–136.

Wardani IS. Tatalaksana Sepsis Berat pada Pasien Lanjut Usia. Jurnal Kedokteran Universitas Mataram. 2017; 7(4): 33–39.

Suwondo VN, Jatmiko HD, Hendrianingtyas M. Karakteristik Dasar Pasien Sepsis yang Meninggal di ICU RSUP Dr.Kariadi Semarang Periode 1 Januari - 31 Desember 2014. Media Medika Muda. 2015; 4(4): 1586–1596.

Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia No. 27 tentang Pedoman Pencegahan dan Pengendalian Infeksi di Fasilitas Pelayanan Kesehatan. Jakarta: Kemenkes RI; 2017. p. 1-172.

Chebl RB, Tamim H, Dagher GA, et al. Sepsis in End-Stage Renal Disease Patients: Are They at an Increased Risk of Mortality? Annals of Medicine. 2021; 53(1): 1737–1743.

Dirga D, Khairunnisa SM, Akhmad AD, Setyawan IA, and Pratama A. Evaluasi Penggunaan Antibiotik pada Pasien Rawat Inap di Bangsal Penyakit Dalam RSUD. Dr. H. Abdul Moeloek Provinsi Lampung. Jurnal Kefarmasian Indonesia. 2021; 11(1): 65–75.

Pandoyo RS, Untari SSM, Perwitasari DA, and Akrom. Utilization Analysis of Antibiotics for Typhoid Fever in Hospitalized Patient in 2010 and 2011 at X Hospital in Bantul with ATC/DDD Method. Proceeding of International Safety Management of Central Cytotoxic Reconstitution. Yogyakarta, 25 May 2013; p. 77–81.

Putri HA, Akrom A, and Risdiana I. Analisis Penggunaan Antibiotik pada Pasien Community-Acquired Pneumonia (CAP) di RS PKU Muhammadiyah Gamping. Jurnal Farmasi Sains dan Praktis. 2021; 7(1): 25–33.

Mahmudah F, Sumiwi SA, and Hartini S. Studi Penggunaan Antibiotik Berdasarkan ATC/DDD dan DU 90% di Bagian Bedah Digestif di Salah Satu Rumah Sakit di Bandung. Jurnal Farmasi Klinik Indonesia. 2016; 5(4): 293–298.

Khilnani GC, Zirpe K, Hadda V, et al. Guidelines For Antibiotic Prescription In Intensive Care Unit. Indian Journal of Critical Care Medicine. 2019; 23(1): 1-63.

Hedi B, Fitri EY, and Hikayati. Faktor-faktor yang Berhubungan dengan Kejadian Systemic Inflammatory Response Syndrome di Ruang ICU RSUD Lahat. Jurnal Keperawatan Sriwijaya. 2017; 4(1): 1–13.

Arumugham VB, Gujarati R, and Cascella M. Third Generation Cephalosporins. (Online) 2019. https://www.statpearls.com/ArticleLibrary/viewarticle/30061.

Downloads

Published

2023-02-27

Versions

Issue

Section

Research Article