Effectiveness of 0.1% Retinol Serum and Astaxanthin Gel on Skin Photoaging


  • Boedhy Setyanto RSUD dr. Saiful Anwar Malang
  • Sinta Murlistyarini RSUD dr. Saiful Anwar Malang
  • Dea Florensia RSUD dr. Saiful Anwar Malang




Astaxanthin, photoaging, retinol


Skin photoaging is cumulative skin damage due to chronic environmental exposure, especially ultraviolet (UV) light, which interferes with the keratinocyte and fibroblast syntheses by matrix metalloproteinases (MMP). Retinol can improve wrinkles, pigmentation, elasticity, firmness, brightness, and various signs of photoaging on the skin. Astaxanthin is a powerful antioxidant that protects the skin from UV rays, inhibits MMP, and stimulates collagen production. This case report presents 2 cases of women complaining about deep skin wrinkles, dullness, and looseness. Physical examination in the facial region revealed wrinkles when resting in the first patient and wrinkles during motion in the second patient. The first patient was diagnosed Glogau III photoaging, while the second patient was diagnosed Glogau II photoaging. Both patients received astaxanthin gel therapy and SPF 33 sunscreen cream every morning, as well as 0.1% retinol serum every night. There was an improvement after six weeks. Astaxanthin and retinol 0.1% can be used as photoaging therapy. Adequate use of photoprotection is also necessary to prevent the worsening of photoaging.


Download data is not yet available.


Huang AH and Chien AL. Photoaging: A Review of Current Literature. Current Dermatology Reports. 2020; 9(1): 22-29.

Cole MA, Quan T, Voorhees JJ, and Fisher GJ. Extracellular Matrix Regulation of Fibroblast Function: Redefining Our Perspective on Skin Aging. Journal of Cell Communication and Signaling. 2018; 12(1): 35-43.

Park MA, Sim MJ, and Kim YC. Anti-Photoaging Effects of Angelica Acutiloba Root Ethanol Extract in Human Dermal Fibroblasts. Toxicological Research. 2017; 33(2): 125-134.

Zahruddin A and Damayanti D. Penuaan Kulit: Patofisiologi dan Manifestasi Klinis. Berkala Ilmu Kesehatan Kulit dan Kelamin. 2018; 30(3): 208-215.

Kostyuk V, Potapovich A, Albuhaydar AR, Mayer W, De Luca C, and Korkina L. Natural Substances for Prevention of Skin Photoaging: Screening Systems in the Development of Sunscreen And Rejuvenation Cosmetics. Rejuvenation Research. 2018; 21(2): 91-101.

Zasada M and Budzisz E. Randomized Parallel Control Trial Checking the Efficacy and Impact of Two Concentrations of Retinol in the Original Formula on the Aging Skin Condition: Pilot Study. Journal of Cosmetic Dermatology. 2020; 19(2): 437-443.

Tetali BBS, Fahs FM, and Mehregan D. Popular Over‐The‐Counter Cosmeceutical Ingredients and Their Clinical Efficacy. International Journal of Dermatology. 2020; 59(4): 393-405.

Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, and Weindl G. Retinoidsi in the Treatment of Skin Aging: an Overview of Clinical Efficacy and Safety. Clinical Interventions in Aging. 2006; 1(4): 327-348.

Mohiuddin AK. Skin Lightening & Management of Hyperpigmentation. American Journal of Dermalotogical Review and Research. 2019; 2(2): 1-66.

Zhang S and Duan E. Fighting Against Skin Aging: The Way from Bench to Bedside. Cell Transplantation. 2018; 27(5): 729-738.

Kang S, Amagai M, Brucner AL, et al. Fitzpatrick's Dermatology. 9th edition. New York: Mc Graw-Hill Education; 2019: p. 3623.

Friedman BJ, Lim HW, and Wang SQ. Photoprotection and Photoaging. In: Wang SQ and Lim HW (Ed). Principles and Practice of Photoprotection 1st edition. Switzerland: Adis; 2016: p. 61-74.

Sparavigna A, Tenconi B, Giori AM, Bellia G, and La Penna L. Evaluation of the Efficacy of a New Hyaluronic Acid Gel on Dynamic and Static Wrinkles in Volunteers with Moderate Aging/Photoaging. Clinical, Cosmetic and Investigational Dermatology. 2019; 12: 81-90.

Yu SH and Baron ED. Evaluation and Assessment of Photoaging. Photonics & Lasers in Medicine. 2013; 2(4): 305-314.

Buranasirin P, Pongpirul K, and Meephansan J. Development of a Global Subjective Skin Aging Assessment Score from the Perspective of Dermatologists. BMC Research Notes. 2019; 12(1): 1-6.

Draelos ZD and Peterson RS. A Double-Blind, Comparative Clinical Study of Newly Formulated Retinol Serums vs Tretinoin Cream in Escalating Doses: A Method for Rapid Retinization with Minimized Irritation. Journal of Drugs in Dermatology. 2020; 19(6): 625-631.

Glogau RGS. Photo Aging and Aging Skin. In: Rigel DS, Weiss RA, Linn HW, Dover JS (Eds). Photoaging 2nd edition. Canada: Maarced Decker Inc; 2003: p. 65-73.

Dhaliwal S, Rybak I, Ellis SR, et al. Prospective, Randomized, Double‐Blind Assessment of Topical Bakuchiol and Retinol For Facial Photoageing. The British Journal of Dermatology. 2019; 180(2): 289-296.

Kikuchi K, Suetake T, Kumasaka N, and Tagami H. Improvement of Photoaged Facial Skin in Middle-Aged Japanese Females by Topical Retinol (Vitamin A Alcohol): A Vehicle-Controlled, Double-Blind Study. Journal of Dermatological Treatment. 2009; 20(5): 276-281.

Kong R, Cui Y, Fisher GJ, et al. A Comparative Study of the Effects of Retinol and Retinoic Acid on Histological, Molecular, and Clinical Properties of Human Skin. Journal of Cosmetic Dermatology. 2016; 15(1): 49-57.

Eren B, Tanrıverdi ST, Köse FA, and Özer Ö. Antioxidant Properties Evaluation of Topical Astaxanthin Formulations as Anti‐Aging Products. Journal of Cosmetic Dermatology. 2019; 18(1): 242-250.

Singh KN, Patil S, and Barkate H. Protective Effects of Astaxanthin on Skin: Recent Scientific Evidence, Possible Mechanisms, and Potential Indications. Journal of Cosmetic Dermatology. 2020; 19(1): 22-27.

Sofiah AS and Lesmana R. Astaxanthin Cream Alters Type I Procollagen and Matrix Metalloproteinase-1 (MMP-1) Gene Expression Induced by Ultraviolet B Irradiation In Rat Skin. Journal ff Biomedical and Clinical Sciences (JBCS). 2018; 3(1): 62-67.



2022-02-28 — Updated on 2022-04-09




Case Report