Three Characterisctics of Atopy to Diagnose Allergy in Children with Respiratory Symptomps
DOI:
https://doi.org/10.21776/ub.jkb.2020.031.02.9Keywords:
Allergy, atopy, respiratory symptoms, skin prick testAbstract
The prevalence of allergic diseases has increased in the last decade. Therefore, precise and reliable in predicting allergy in children were needed. However, in daily practice, most misdiagnosis occurs because it is only based on a family history of allergy. This study aims to evaluate the chronicity, recurrence of symptoms with similar exposure, and family history of allergy to be used as a predictor of allergy in children with respiratory symptoms. Cross sectional study was conducted in children who referred to the Pediatric Allergy and Immunology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 1st - July 31st 2019. Children with a suspected allergy who developed respiratory symptoms was included. The data was taken from standardized medical record. The sensitivity and specificity of the 3 characteristics of atopic with positive SPT were calculated. A total of 115 children were admitted and 109 children fulfill the inclusion criteria. Gender 60% male and 40% female. The most common group of age founded was age 5-<10 years 39.4%, followed by 1-<3 years (25.8%), 3-<5 years (22.9%), 10 years 8.3%, and <1 year (3.6%). Fifty-four patients (49.5%) fulfilled 3 characteristics of atopy and there were 64 patients (58.7%) with positive SPT results. The sensitivity, specificity, positive predictive value and negative predictive value were 81.3%, 95.6%, 96.3%, and 78.2%, respectively. The 3 characteristics of atopy have good sensitivity and specificity to predict allergy in children.
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Kansen HM, Le TM, Uiterwaal CSPM, et al. Prevalence And Predictors Of Uncontrolled Asthma In Children Referred For Asthma And Other Atopic Diseases. J Asthma Allergy. 2020;13:67–75.
Dorey HF, Dorey JM, Burman NJ, et al. Observations Of Pediatric Disease Prevalence From Pacific Partnership 2015. Military Medicine. 2018;183(April):530–7.
Gough H, Grabenhenrich L, Reich A, et al. Allergic Multimorbidity Of Asthma, Rhinitis And Eczema Over 20 Years In The German Birth Cohort MAS. Pediatric Allergy and Immunology. 2015;26(5):431–7.
Endaryanto A. Implikasi Klinis Imunologi Alergi. 1st ed. Surabaya: Airlangga University Press (AUP); 2015.
Far-Far I, Endaryanto A, and Setyoningrum RA. Instrumen - Poli Alergi RSUD Dr. Soetomo.Docx. figshare. Preprint. 2020: Available from: https://doi.org/10.6084/m9.figshare.12022488.v2
Zhao J, Bai J, Shen K, et al. Self-Reported Prevalence Of Childhood Allergic Diseases In Three Cities Of China: A Multicenter Study. BMC Public Health. 2010;10(551).
Ebert CS, and Pillsbury HC. Epidemiology Of Allergy. Otolaryngol Clin N Am. 2011;44(3):537–48.
Larenas-Linnemann D, Luna-Pech JA, and Mösges R. Debates In Allergy Medicine: Allergy Skin Testing Cannot Be Replaced By Molecular Diagnosis In The Near Future. World Allergy Organ J. 2017;10(1):1–7.
Rahajoe N, Kartasasmita CB, Supriyatno B, and Setyanto DB. Pedoman Nasional Asma Anak. 2nd ed. Vol. 2. Surabaya: UKK Respirologi PP Ikatan Dokter Anak Indonesia; 2016: 5. p.
Platts-Mills, TA Thomas, WR Aalberse, RC Vervloet, D Champman M. Dust Mite Allergens And Asthma: Report Of A Second International Workshop. J Allergy Clin Immunol. 1992;89(5):1046–60.
Squillace SP, Sporik RB, Rakes G, et al. Sensitization To Dust Mites As A Dominant Risk Factor For Asthma Among Adolescents Living In Central Virginia: Multiple Regression Analysis Of A Population-Based Study. Am J Respir Crit Care Med. 1997;156(6):1760–4.
Gøtzsche PC, and Johansen HK. House Dust Mite Control Measures For Asthma: Systematic Review. Allergy: European Journal of Allergy and Clinical Immunology. 2008;63(6):646–59.
Schei MA, Hessen JO, and Lund E. House-Dust Mites And Mattresses. Allergy. 2002;57(6):538–42.
Baena-Cagnani CE TA. Role Of Food Allergy In Asthma In Childhood. Curr Opin Allergy Clin Immunol. 2001;1(2):145–9.
Wistiani HN. Hubungan Pajanan Alergen Terhadap Kejadian Alergi Pada Anak. Sari Pediatri. 2011;13(3):185–90. Available from: https://saripediatri.org/index.php/sari-pediatri/article/view/431
Kaswandani N, Mirtha L, Soegiharto B, et al. Kiat Membuat Anak Sehat, Tinggi, Dan Cerdas. In: Tata Laksana Anak dengan ISPA Berulang: Mencegah Terus Berulang. Surabaya: Ikatan Dokter Anak Indonesia Cabang DKI Jakarta; 2016: p. 71–8. Available from: http://fk.ui.ac.id/wp-content/uploads/2017/05/Buku-PKB-Jaya-XIII-Nov-2016.pdf
Mathur AK, Stern DA, Daines MO, Wright AL, Martinez FD, and Carr TF. Sensitivity And Specificity Of A Clinical Diagnosis Of Allergic Rhinitis In Childhood. Journal of Allergy and Clinical Immunology. 2016;137(2):AB163. Available from: http://dx.doi.org/10.1016/j.jaci.2015.12.664
Mutius V, and Th Nicolai E. Familial Aggregation Of Asthma In A South Bavarian Population. Am J Respir Crit Care Med. 1997;153(4 Pt1):1266–72.
Zuidmeer L, Goldhahn K, Rona RJ, et al. The Prevalence Of Plant Food Allergies: A Systematic Review. J Allergy Clin Immunol. 2008;121(5):1210–8.
Turner P, Ng I, Kemp A, and Campbell D. Seafood Allergy In Children: A Descriptive Study. Ann Allergy Asthma Immunol. 2011;106(6):494–501.
Annesi-Maesano I, Didier A, Klossek M, Chanal I, Moreau D, and Bousquet J. The Score For Allergic Rhinitis (SFAR): A Simple And Valid Assessment Method In Population Studies. Allergy: European Journal of Allergy and Clinical Immunology. 2002;57(2):107–14.
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