Perbedaan Kadar Laktat Dehidrogenase (LDH) pada Berbagai Derajat Keparahan Preeklampsia

Authors

  • Tendi Novara Fakultas Kedokteran Universitas Jenderal Soedirman RSUD Prof. Dr. Margono Soekarjo Purwokerto
  • Ika Murti Harini Fakultas Kedokteran Universitas Jenderal Soedirman
  • Sutrisno Sutrisno Fakultas Kedokteran Universitas Jenderal Soedirman RSUD Prof. Dr. Margono Soekarjo Purwokerto

DOI:

https://doi.org/10.21776/ub.jkb.2019.030.04.7

Keywords:

Derajat keparahan preeklampsia, laktat dehidrogenase, normotensi, preeklampsia berat (PEB), preeklampsia ringan (PER)

Abstract

Preeklampsia adalah penyakit kehamilan akibat disfungsi plasenta serta merupakan penyebab kesakitan dan kematian maternal maupun perinatal di Indonesia. Laktat dehidrogenase (LDH) adalah enzim intraseluler yang dapat menandai adanya jejas pada sel dan jaringan. Penelitian ini bertujuan untuk mengetahui perbedaan kadar LDH pada berbagai derajat keparahan preeklampsia. Penelitian ini menggunakan desain analitik observasional dengan pendekatan kasus kontrol. Subjek dibagi menjadi 3 kelompok yaitu normotensi, preeklampsia ringan (PER) dan preeklampsia berat (PEB). Data dianalisis menggunakan uji Kruskal-Wallis dan Mann Whitney. Hasil penelitian didapatkan perbedaan kadar LDH antara kelompok normotensi dengan PER (p=0,031) dan antara normotensi dengan PEB (p=0,039) dengan kadar LDH pada PEB secara bermakna paling rendah dibandingkan dengan PER dan normotensi.

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Author Biographies

Tendi Novara, Fakultas Kedokteran Universitas Jenderal Soedirman RSUD Prof. Dr. Margono Soekarjo Purwokerto

Departemen Anestesi dan Terapi Intensif

Ika Murti Harini, Fakultas Kedokteran Universitas Jenderal Soedirman

Departemen Histologi

Sutrisno Sutrisno, Fakultas Kedokteran Universitas Jenderal Soedirman RSUD Prof. Dr. Margono Soekarjo Purwokerto

Departemen Obstetri dan Ginekologi

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Published

2019-08-30

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Section

Research Article